Inhibitors of Protein Tyrosine Kinase pp^{60^v-src}: Sterol Sulfates from the Brittle Star Ophiarachna incrassata

Abstract

Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp60v-src inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All five compounds were found to inhibit protein tyrosine kinase pp 60v-src.