Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

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Medicine, Dermatology, Oncology +17

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Life Sciences, Biology, Cell Biology +12

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

Chao‐Lan Yu, Debra J. Meyer, George S. Campbell et al. · Science · 1995 · 943 citations

Life Sciences, Cell Biology, Molecular Biology +16

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial

Gerald S. Falchook, Georgina V. Long, Razelle Kurzrock et al. · The Lancet · 2012 · 933 citations · Full text

Medicine, Oncology, Pharmacotherapy +12

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida et al. · Proceedings of the National Academy of Sciences · 2007 · 743 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14