Organic Letters · 2010 · 23 citations · 22 references
Natural SciencesBiochemistryChemistryBiomolecular ModelingEnzymologyInorganic ChemistryCluster ChemistryCoordination ChemistryLigand BindingMetal-ligand BondingProtein-ligand BindingTransition Metal ComplexesArene CoordinationBioinorganic Coordination ChemistryGuest Binding SelectivityIntermolecular Metal-ligand InteractionsMetal Ion CoordinationMetal Ion Coordination SitesMetal Ligand CoordinationMetal-ligand Bonding In Enzymes
The bowl-shaped resorcin[4]arene-based ligand was prepared as a model of the trihistidine coordination core present in many mononuclear metalloenzymes. The -CH(2)-O-CH(2)- linkers connecting the imidazoles to the cavity allow three imidazoles to simultaneously bind a metal ion, and favor cis-coordination of two exchangeable ligands. The corresponding mononuclear Zn(II) complexes were shown to be capable of the selective guest binding and exchange at both endo and exo positions.
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Peter Timmerman, Willem Verboom, David N. Reinhoudt · Tetrahedron · 1996 · 606 citations · Full text