Batzelladines F−I, Novel Alkaloids from the Sponge <i>Batzella </i>sp.: Inducers of p56^lck-CD4 Dissociation

Abstract

The sponge Batzella sp. from Jamaica contains four new alkaloids, batzelladines F−I (1-4), that induce the p56lck−CD4 dissociation. Batzelladines F−I were isolated using a bioassay-directed fractionation scheme and were identified by interpretation of spectroscopic data. Batzelladines F, G, and H + I were active in the p56lck−CD4 dissociation assay at micromolar concentrations.