Concepedia

Cyanogen Bromide-Induced Chemical Ligation: Mechanism and Optimization of the Reaction Conditions

Marina Gottikh, T. S. Oretskaya

Nucleosides and Nucleotides · 1996 · 27 citations · 9 references

DOI

Concepts

Abstract

Abstract Chemical ligation induced by BrCN in the presence of N-substituted morpholine has been studied in details. It has also been shown that the phosphate activation by BrCN can be used for the synthesis of nucleotide derivatives in aqueous solutions.

References

9

A Nonenzymatic RNA Polymerase Model

Takuro Inoue, L.E. Orgel · Science · 1983 · 268 citations

, , +10

Molecular recognition by circular oligonucleotides: increasing the selectivity of DNA binding

Eric T. Kool · Journal of the American Chemical Society · 1991 · 102 citations

, , +8

Oligonucleotide circularization by template-directed chemical ligation

Nina G. Dolinnaya, Marta Blumenfeld, I. N. Merenkova et al. · Nucleic Acids Research · 1993 · 87 citations · Full text

, , +13

Template-directed polymerization of oligoadenylates using cyanogen bromide

Eiko Kanaya, Hiroshi Yanagawa · Biochemistry · 1986 · 81 citations

, , +8

DNA-like duplexes with repetitions. III. Efficient template-guided chemical polymerization of d(TGGCCAAGCTp)

Nina G. Dolinnaya, N.P. Mehiikova, Andrei A. Purmal · Nucleic Acids Research · 1981 · 46 citations

, , +16