The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus

Abstract

A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 mug cm(-3) for Hexaene H-85 and 118 mug cm(-3) for Azalomycine B. The impact of modified media on soil morphology also was investigated.