Crystal Structure of Cyclosporin E

Abstract

The structure of cyclosporin E was determined by X-ray diffraction methods and compared with the structure of related cyclosporins. In contrast to cyclosporin A, which crystallizes from acetone as tetragonal dihydrate, cyclosporin E acetone solvate monohydrate (C 61 H 109 N 11 O 12 ·C 3 H 6 O·H 2 O) crystallizes under the same conditions in the monoclinic space group P2 1 with a = 15.698(2) Å, b = 21.333(3) Å, c = 13.224(2) Å, β = 103.74(1)°, Z = 2, and V = 4 302(1) Å 3 .