Concepedia

Dendronized Gold Nanoparticles for siRNA Delivery

Sung Tae Kim, Apiwat Chompoosor, Yi‐Cheun Yeh, Sarit S. Agasti, David J. Solfiell, Vincent M. Rotello

Small · 2012 · 115 citations · 17 references

DOI

Concepts

Abstract

Dendronized gold nanoparticles (AuNPs) are effective nanocarriers for small interfering RNA (siRNA) delivery. Electrostatic condension of these AuNPs with siRNA provides efficient silencing (∼50%) without cytotoxicity.

References

17

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity

John O’Brien, Ian D. Wilson, Terry C. Orton et al. · European Journal of Biochemistry · 2000 · 3.4K citations · Full text

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Monolayer-Protected Cluster Molecules

Allen C. Templeton, W. Peter Wuelfing, Royce W. Murray · Accounts of Chemical Research · 1999 · 2.4K citations

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Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

David A. Giljohann, Dwight S. Seferos, Andrew E. Prigodich et al. · Journal of the American Chemical Society · 2009 · 627 citations · Full text

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Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells

Mini Thomas, Alexander M. Klibanov · Proceedings of the National Academy of Sciences · 2003 · 548 citations · Full text

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Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles

P. S. Ghosh, Chaekyu Kim, Gang Han et al. · ACS Nano · 2008 · 457 citations · Full text

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