Concepedia

Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma

Olga Lyass, Beatrice Uziely, Rami Ben‐Yosef, Dinah Tzemach, Norman I. Heshing, Michal Lotem, G Brufman, Alberto Gabizon

Cancer · 2000 · 387 citations · 29 references

Open access

Abstract

The toxicity of Doxil is dose and schedule dependent and well correlated with pharmacokinetic parameters. Pharmacokinetic guidance of Doxil dosing may be a useful tool.

References

29

Risk Factors for Doxorubicin-lnduced Congestive Heart Failure

Daniel D. Von Hoff · Annals of Internal Medicine · 1979 · 2.4K citations

Drug Safety, Potential Risk Factors, Heart Failure +13

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.

Alberto Gabizón, Raphael Catane, Beatrice Uziely et al. · PubMed · 1994 · 1.4K citations

Engineering, Circulation Time, Pathology +22

Dermatology in General Medicine

Philip C. Anderson · JAMA · 1994 · 1.2K citations

Biology, Elegant Textbook, Thomas Fitzpatrick +12

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Fan Yuan, Michael Leunig, S.K. Huang et al. · PubMed · 1994 · 912 citations

Microvascular Permeability, Engineering, Extracellular Microvesicles +16

Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation.

Franco M. Muggia, John D. Hainsworth, Susan Jeffers et al. · Journal of Clinical Oncology · 1997 · 656 citations