Concepedia

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors

Susan E. Morgan-Lappe, Keith W. Woods, Q Li, M G Anderson, Mark E. Schurdak, Yan Luo, Vincent L. Giranda, Stephen W. Fesik

Oncogene · 2005 · 53 citations · 33 references

DOI

Concepts

References

33

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

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Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

, , +17

Expression profiling reveals off-target gene regulation by RNAi

Aimee L. Jackson, Steven R. Bartz, Janell M. Schelter et al. · Nature Biotechnology · 2003 · 2.4K citations

, , +11

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Gabriele Bergers, Steven Song, Nicole Meyer-Morse et al. · Journal of Clinical Investigation · 2003 · 1.2K citations

, , +17

Analysis of gene function in somatic mammalian cells using small interfering RNAs

Sayda M. Elbashir · Methods · 2002 · 1.1K citations · Full text

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