A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of Xanthohumol

Abstract

Background: Xanthohumol may be beneficial for obesity-related conditions, but mechanisms are unknown. Results: XN lowers ROS and dysfunctional lipid metabolism in animals, and XN uncouples respiration and induces oxidant defense systems in myocytes. Conclusion: XN may ameliorate metabolic syndrome by these mechanisms.