Deprotonation of Benzylic Ethers Using a Hindered Phosphazene Base. A Synthesis of Benzofurans from <i>Ortho</i>-Substituted Benzaldehydes

George A. Kraus, Ning Zhang, John G. Verkade, M. Nagarajan, Philip Kisanga

Organic Letters · 2000 · 72 citations · 14 references

Concepts

Abstract

The hindered nonionic phosphazene base P(4)-t-Bu efficiently deprotonates o-arylmethoxy benzaldehydes, leading to a direct synthesis of benzofurans. Strong ionic bases such as LDA, LiTMP, and KH failed.

References

14