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Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*
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2005
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ImmunologyPharmacotherapyAntiviral DrugPharmaceutical ChemistryMedicinal ChemistryHuman RetrovirusAntiviral Drug DevelopmentRecent ProgressHivPharmacologyAntiviral CompoundCxcr4 AntagonistsAntiviral ResponseAntiviral TherapyNew Ccr5MedicineAnti-hiv DrugsDrug DiscoveryHiv-1 Entry
This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.