Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

Berkley A. Lynch, Nathalie Lambeng, Karl Nocka et al. · Proceedings of the National Academy of Sciences · 2004 · 1.6K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study

Waldemar A. Turski, Ésper A. Cavalheiro, Michael Schwarz et al. · Behavioural Brain Research · 1983 · 1.1K citations

Medicine, Neuroscience, Pharmacology +11

Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures

Ésper A. Cavalheiro, João Pereira Leite, Z A Bortolotto et al. · Epilepsia · 1991 · 612 citations

Medicine, Neurology, Neuroscience +15

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

Henrik Klitgaard, Alain Matagne, J.G. Gobert et al. · European Journal of Pharmacology · 1998 · 509 citations

Medicine, Neuroscience, Pharmacology +12

Antiepileptogenic Effects of the Novel Anticonvulsant Levetiracetam (ucb L059) in the Kindling Model of Temporal Lobe Epilepsy

Wolfgang Löscher, Dagmar Hönack, Chris Rundfeldt · Journal of Pharmacology and Experimental Therapeutics · 1998 · 345 citations

Medicine, Pharmacokinetics, Pharmacology +13