“Click” Xylosides Initiate Glycosaminoglycan Biosynthesis in a Mammalian Cell Line

Abstract

A good GAG. In order to modulate glycosaminoglycan (GAG) biosynthesis, and determine their physiological and developmental role in a spatiotemporal manner, we synthesized a library of “click” xylosides with various aglycone moieties that are very stable under physiological conditions. The synthesized compounds were examined for their ability to stimulate GAG chains in a cell line that is defective in the production of GAG chains.