Intact Learning of New Relations in Amnesia as Achieved through Unitization

Abstract

Hippocampal amnesia is defined by deficits in the binding of relations among items--a deficit captured by the transverse patterning (TP) task. Unitization is a processing mechanism that may allow amnesic patients to compensate for relational memory deficits. Amnesic patient D.A. demonstrated intact TP, and performance was maintained 1 month following training. Successful acquisition of relations occurred only when D.A. fused or integrated objects into a unified representation. D.A. did not acquire relations when he did not generate such integrated scenarios, and acquisition of relations was slowed when integration had to occur for novel stimuli. Amnesic patients K.C. and R.F.R. were tested to provide comparative data; K.C. and R.F.R. did not benefit from unitization, perhaps due to additional cortical damage. We propose that unitization requires visual imagery of multiple items that are fused/integrated; through the benefit of extended on-line maintenance, this fused representation is anchored to existing representations in semantic memory.