Stabilization of a recombinant Fv fragment bybase-loop interconnection and VH-VL permutation

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

F. William Studier, Barbara A. Moffatt · Journal of Molecular Biology · 1986 · 6.4K citations

Life Sciences, Microbiology, Molecular Biology +9

Sequences of proteins of immunological interest

Analytical Biochemistry · 1984 · 3.4K citations

Life Sciences, Immunology, Molecular Biology +10

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Engineering, Biochemistry, Molecular Biology +17

Single-Chain Antigen-Binding Proteins

Robert E. Bird, Karl D. Hardman, James W. Jacobson et al. · Science · 1988 · 1.5K citations

Pharmacy, Biochemistry, Molecular Biology +13

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

Takashi Uchiyama, S Broder, Thomas A. Waldmann · The Journal of Immunology · 1981 · 1.3K citations · Full text

Life Sciences, Cell Biology, Immunology +16