Cardiospecific Overexpression of the Prostaglandin EP ₃ Receptor Attenuates Ischemia-Induced Myocardial Injury

Abstract

Constitutive prostaglandin EP3 receptor signaling exerts a protective effect on cardiomyocytes, which is probably Gi mediated and results in a remarkable attenuation of myocardial injury during ischemia and reperfusion. Cardioprotective actions of E-type prostaglandins may be mediated by this receptor subtype.