Concepedia

Plasma Membrane Calcium ATPase Isoform 4 Inhibits Vascular Endothelial Growth Factor–Mediated Angiogenesis Through Interaction With Calcineurin

Rhiannon R Baggott, Arántzazu Alfranca, Dolores López-Maderuelo, Tamer Mohamed, Amelia Escolano, Jorge Oller, Beatriz C. Ornes, Sathishkumar Kurusamy, Farjana B. Rowther, James Brown,

Arteriosclerosis Thrombosis and Vascular Biology · 2014 · 48 citations · 36 references

DOIFull text

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Abstract

Given the importance of the calcineurin/NFAT pathway in the regulation of pathological angiogenesis, targeted modulation of PMCA4 functionality might open novel therapeutic avenues to promote or attenuate new vessel formation in diseases that occur with angiogenesis.

References

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Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a

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Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility

Kai Schuh, Elizabeth J. Cartwright, Eriks Jankevics et al. · Journal of Biological Chemistry · 2004 · 270 citations · Full text