Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

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Comparison of Human Duodenum and Caco-2 Gene Expression Profiles for 12,000 Gene Sequences Tags and Correlation with Permeability of 26 Drugs

Duxin Sun, Hans Lennernäs, Lynda S. Welage et al. · Pharmaceutical Research · 2002 · 441 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +11

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model

Florence Delié, Werner Rubas · Critical Reviews in Therapeutic Drug Carrier Systems · 1997 · 437 citations

Life Sciences, Biochemistry, Cell Biology +17