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Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

Autoimmune DiseaseAdaptive Immune SystemT-regulatory CellPathogenesisImmunologySelf PeptidePeripheral ComplexesAutoimmunitySelf-toleranceCd4 T Cell ResponsesAntigen ProcessingCellular Immune ResponseMedicineImmunological Memory