Structural properties of aqueous metoprolol succinate solutions. Density, viscosity, and refractive index at 311 K

Abstract

Density, viscosity and refractive index of aqueous solutions of metoprolol succinate of different concentrations (0.005–0.05 mol dm −3 ) were measured at 38°C. Apparent molar volume of resultant solutions were calculated and fitted to the Masson’s equation and apparent molar volume at infinite dilution was determined graphically. Viscosity data of solutions has been fitted to the Jone-Dole equation and viscosity A - and B -coefficients were determined graphically. Physicochemical data obtained were discussed in terms of molecular interactions.