Examining the Basis of Isoniazid Tolerance in Nonreplicating <i>Mycobacterium Tuberculosis</i> Using Transcriptional Profiling

Abstract

The differential regulation (between drug-free NRP2 and log-phase bacilli) of genes directly implicated in INH resistance could not account for the abrogation of INH killing in nongrowing bacilli. Thus, factors affecting the requirement for mycolic acids and the redox status of bacilli are likely responsible for the reduction in INH efficacy. We speculate on additional mechanisms revealed by transcriptome analysis that might account for INH tolerance.