International Journal of Developmental Neuroscience · 2006 · 87 citations · 16 references
Life SciencesCell BiologyNeuroscienceCell SignalingCellular NeuroscienceSignal TransductionCell Signaling In NeuronsGlucagon-like Peptide-1 Receptor AgonistsIncretin-based TherapiesNeural DifferentiationNeuroprotectionNeurotrophic FactorsAgonist ActivityGlucagon-like Peptide 1 Receptor AgonismGlucagon-like Peptide-1 Receptor SignalingGlucagon-like PeptidesMek InhibitionMek InhibitorsMitogen-activated Protein Kinase PathwaysSmall-molecule Glp-1 Receptor Agonists
The emerging data show that the insulinotrophic hormone glucagon-like peptide-1(GLP-1) and its agonist extendin-4 have neurotrophic function to inducing neuronal differentiation of PC12 cells and prevent neurons damage challenged by oxidative stress. Here, with the model of high throughput screen for GLP-1 receptor agonists, we screen and identify that geniposide is a novel agonist for GLP-1 receptor. Furthermore, geniposide induces the neuronal differentiation of PC12 cells with resulting neurites outgrowth; we also observe an increase in expression of growth-associated protein-43. U0126, a selective MEK inhibitor, prevents neurites out growth and phosphorylation of mitogen-activated kinase proteins in PC12 cells induced by geniposide. All these results show that activation of GLP-1 receptor by geniposide to induce the neuronal differentiation of PC12 cells involves in MAPK signaling cascade.
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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During, Lei Cao, David S. Zuzga et al. · Nature Medicine · 2003 · 844 citations