Adaptive evolution by optimizing expression levels in different environments

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

Rafael U. Ibarra, Jeremy S. Edwards, Bernhard Ø. Palsson · Nature · 2002 · 879 citations

Life Sciences, Evolutionary Biology, Microbiology +13

Optimality and evolutionary tuning of the expression level of a protein

E. Dekel, Uri Alon · Nature · 2005 · 833 citations

Life Sciences, Bioinformatics, Molecular Biology +14

Systematic changes in gene expression patterns following adaptive evolution in yeast

Tracy Ferea, David Botstein, Patrick O. Brown et al. · Proceedings of the National Academy of Sciences · 1999 · 486 citations

Life Sciences, Biology, Genetics +16

In silico design and adaptive evolution of <i>Escherichia coli</i> for production of lactic acid

Stephen S. Fong, Anthony P. Burgard, Christopher D. Herring et al. · Biotechnology and Bioengineering · 2005 · 366 citations

Life Sciences, Bioengineering, Biotechnology +17

Parallel adaptive evolution cultures of<i>Escherichia coli</i>lead to convergent growth phenotypes with different gene expression states

Stephen S. Fong, Andrew R. Joyce, Bernhard Ø. Palsson · Genome Research · 2005 · 280 citations · Full text

Life Sciences, Evolutionary Biology, Microbiology +17