Long‐chain fatty acid uptake and oxidation in the perfused liver of Walker‐256 tumour‐bearing rats

Abstract

Ketogenesis from exogenous fatty acids is decreased in the livers of Walker-256 tumour-bearing rats in consequence of the diminished activity of the mitochondrial CAT I. The lower rates of oxygen uptake indicate a decreased ATP synthesis, which is consistent with the in vivo lower phosphorylation potential.