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Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments

Amino Acid OccurrencesProtein FoldingGeneticsNatural SciencesComputational BiologyDirected EvolutionMolecular BiologyProtein EvolutionNatural SelectionProtein EngineeringKinetic StabilityGene EvolutionSequence AlignmentMolecular AdaptationMedicineBioinformatics