Sensitive femtosecond coherent anti-Stokes Raman spectroscopy discrimination between dipicolinic acid and dinicotinic acid

Abstract

We demonstrate that femtosecond ultraviolet and visible coherent anti-Stokes Raman spectroscopy provides the sensitivity and specificity needed to distinguish between two similar molecules of pyridinedicarboxylic acid. The Fourier transforms of the temporal measurements provide the energy difference between the ground state vibrational modes. Quantum chemical calculations provide theoretical predictions that agree well with the measurements. The present technique allows us to distinguish 10 cm(-1) frequency shifts by using pulses ten times broader than the shifts.