Effects of AT1 Receptor Blockade on Plasma Thromboxane A<sub>2</sub> (TXA<sub>2</sub>) Level and Skin Microcirculation in Young Healthy Women on Low Salt Diet

Abstract

These data suggest that inhibition of AT1 receptors could lead to activation of AT2 receptors, which maintain hyperemia, despite the increased level of vasoconstrictor TXA2. These findings also suggest an important role of crosstalk between renin-angiotensin system (RAS) and arachidonic acid metabolites in the regulation of microcirculation under physiological conditions.