Concepedia

Synthesis of a hybrid fullerene–trimethoxyindole–oligonucleotide conjugate

Massimo Bergamin, Tatiana Da Ros, Giampiero Spalluto, Alexandre S. Boutorine

Chemical Communications · 2001 · 33 citations · 9 references

DOI

Concepts

Abstract

The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxy- indole-2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.

References

9

Addition of azomethine ylides to C60: synthesis, characterization, and functionalization of fullerene pyrrolidines

Michele Maggini, Gianfranco Scorrano · Journal of the American Chemical Society · 1993 · 1.3K citations

, , +9

Fulleropyrrolidines:  A Family of Full-Fledged Fullerene Derivatives

Michele Maggini · Accounts of Chemical Research · 1998 · 823 citations

, , +7

CC‐1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

Dale L. Boger, Douglas S. Johnson · Angewandte Chemie International Edition in English · 1996 · 319 citations

, , +12

Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage

Alexandre S. Boutorine, Masashi Takasugi, Claude Hélène et al. · Angewandte Chemie International Edition in English · 1995 · 236 citations

, , +16

Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition

Eiichi Nakamura, Hidetoshi Tokuyama, Shigeru Yamago et al. · Bulletin of the Chemical Society of Japan · 1996 · 188 citations

, , +15