Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.9K citations

Life Sciences, Immunology, Molecular Biology +16

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, Daniel C. Rowe et al. · Nature Immunology · 2003 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +6

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Taro Kawai, Ken Takahashi, Shintaro Sato et al. · Nature Immunology · 2005 · 2.5K citations

Life Sciences, Immunology, Molecular Biology +12

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Hiroki Kato, Shintaro Sato, Mitsutoshi Yoneyama et al. · Immunity · 2005 · 1.3K citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori et al. · The Journal of Immunology · 2002 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +17