Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.

TLDR

Platelet‑derived growth factor is a potent mitogen for mesenchymal cells and is expressed in inflammatory conditions such as glomerulonephritis. The study aimed to determine whether PDGF mediates the fibroproliferative responses that characterize these disorders. Neutralizing anti‑PDGF IgG or control IgG was administered to rats with mesangial proliferative nephritis. Inhibition of PDGF markedly reduced mesangial cell proliferation and largely prevented extracellular matrix deposition, suggesting a central role for PDGF in proliferative glomerular disease.

Abstract

Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease.