Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

Heather E. Ryan, M Poloni, William McNulty et al. · PubMed · 2000 · 790 citations

Medicine, Genetics, Oncology +17

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

Helen Le-Niculescu, Emanuela Bonfoco, Yoshitoshi Kasuya et al. · Molecular and Cellular Biology · 1999 · 467 citations

Life Sciences, Neurobiology, Neuroscience +17

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis et al. · International Journal of Radiation Oncology*Biology*Physics · 2002 · 353 citations

Medicine, Oncology, Radiation Oncology +14

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

Michèle Milella, Steven M. Kornblau, Zeev Estrov et al. · Journal of Clinical Investigation · 2001 · 310 citations · Full text

Medicine, Cancer Biology, Oncology +17

Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line

Mariangela Mancini, Benjamin O. Anderson, Elizabeth Caldwell et al. · The Journal of Cell Biology · 1997 · 307 citations · Full text

Life Sciences, Cell Biology, Oncology +16