Concepedia

Macromolecular Crowding Meets Tissue Engineering by Self‐Assembly: A Paradigm Shift in Regenerative Medicine

Abhigyan Satyam, Pramod Kumar, Xingliang Fan, Alexander Gorelov, Yury Rochev, Lokesh Joshi, Héctor Peinado, David Lyden, B.W.J. Thomas, Brian J. Rodriguez,

Advanced Materials · 2014 · 179 citations · 63 references

Open access

Abstract

MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.

References

63

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

James G. Rheinwatd, Howard Green · Cell · 1975 · 4.5K citations

Life Sciences, Cell Biology, Microbiology +6

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

Eugene Bell, Bodil Ivarsson, Charlotte Merrill · Proceedings of the National Academy of Sciences · 1979 · 2.1K citations · Full text

Engineering, Bioengineering, Cell Biology +17

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial

Eriko Tateishi-Yuyama, Hiroaki Matsubara, Toyoaki Murohara et al. · The Lancet · 2002 · 1.7K citations

Medicine, Rehabilitation Medicine, Surgery +16

Corneal Reconstruction with Tissue-Engineered Cell Sheets Composed of Autologous Oral Mucosal Epithelium

Kohji Nishida, Masayuki Yamato, Yasutaka Hayashida et al. · New England Journal of Medicine · 2004 · 1.5K citations · Full text

Medicine, Ophthalmology, Surgery +16

A completely biological tissue-engineered human blood vessel

Nicolas L’Heureux, Stéphanie Pâquet, Raymond Labbé et al. · The FASEB Journal · 1998 · 1.3K citations

Engineering, Bioengineering, Biomedical Engineering +15