Impact of Fibrinogen Levels on Outcomes after Acute Injury in Patients Requiring a Massive Transfusion

Abstract

For patients undergoing a massive transfusion after injury, as the fibrinogen level increased, a stepwise improvement in survival was noted. A fibrinogen level ≤100 mg/dL was a strong independent risk factor for death. The impact of an aggressive fibrinogen replacement strategy using readily available products warrants further prospective evaluation.