Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases

Utilization of operational schemes for analog synthesis in drug design

John G. Topliss · Journal of Medicinal Chemistry · 1972 · 459 citations

Pharmacy, Medicinal Chemistry, Pharmacology +5

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase

Stéphane Bach, Marie Knockaert, Jens Reinhardt et al. · Journal of Biological Chemistry · 2005 · 349 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Tania Tahtouh, Jonathan M. Elkins, P. Filippakopoulos et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

Isidró Ferrer, Marta Barrachina, Berta Puig et al. · Neurobiology of Disease · 2005 · 175 citations · Full text

Life Sciences, Genetics, Neuroscience +14

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

Mansour Debdab, François Carreaux, Stéven Renault et al. · Journal of Medicinal Chemistry · 2011 · 148 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17