Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels

Distinctive chromatin in human sperm packages genes for embryo development

Saher Sue Hammoud, David A. Nix, Haiying Zhang et al. · Nature · 2009 · 1.3K citations

Life Sciences, Genetics, Molecular Biology +16

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

Chun‐Xiao Song, Keith E. Szulwach, Ye Fu et al. · Nature Biotechnology · 2010 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +7

DNA Methylation Decreases in Aging But Not in Immortal Cells

Vincent L. Wilson, Peter A. Jones · Science · 1983 · 654 citations

Education, Cell Biology, Genetics +15

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

Colm E. Nestor, Raffaele Ottaviano, James P. Reddington et al. · Genome Research · 2011 · 409 citations · Full text

Life Sciences, Biology, Genetics +15

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm

Andrew J. Wyrobek, Brenda Eskenazi, Suzanne Young et al. · Proceedings of the National Academy of Sciences · 2006 · 398 citations · Full text

Medicine, Genetics, Molecular Genetics +17