Concepedia

The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension

Tarek Hakki, Katja Hübel, Herbert Waldmann, Rita Bernhardt

The Journal of Steroid Biochemistry and Molecular Biology · 2010 · 28 citations · 25 references

DOI

Concepts

References

25

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

Bertram Pitt, Faı̈ez Zannad, Willem J. Remme et al. · New England Journal of Medicine · 1999 · 9.1K citations · Full text

, , +16

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

, , +16

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

Sergio Moreno, Amar J. S. Klar, Paul Nurse · Methods in enzymology on CD-ROM/Methods in enzymology · 1991 · 3.8K citations

, , +10

The EPHESUS Trial: Eplerenone in Patients with Heart Failure Due to Systolic Dysfunction Complicating Acute Myocardial Infarction

Bertram Pitt, Gordon H. Williams, Willem J. Remme et al. · Cardiovascular Drugs and Therapy · 2001 · 361 citations

, , +15

The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex

Kathleen M. Curnow, M T Tusié-Luna, Leigh Pascoe et al. · Molecular Endocrinology · 1991 · 358 citations · Full text

, , +17