AIDS · 2004 · 131 citations · 1 references
MedicinePharmacokineticsPharmacologyClinical PharmacologyInfectious Disease PharmacotherapyPharmacodynamicsAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyAntiviral TherapyEssential MedicinesMedicinal PlantsAntiretroviral ToxicityCytochrome P450 3A4 MetabolismHerb-drug Metabolism InteractionsMechanisms Of Herb-drug InteractionMedicinal HerbsPharmacodynamics Of Antiretroviral TherapyPharmacokinetics Of Antiretroviral DrugsResistance To Viral Infection
We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.
1