The Effect of Propofol on Increased Superoxide Concentration in Cultured Rat Cerebrocortical Neurons After Stimulation of N-Methyl-d-Aspartate Receptors

Abstract

The neuroprotective properties of propofol may be because of its action as an antioxidant. To investigate whether propofol reduces the N-methyl-D-aspartate-induced increase in superoxide anion levels, the fluorescence of dihydroethidium acetoxymethylester, as an indicator for cellular superoxide concentration, was measured in cultured rat forebrain neurons.