First Clinical Experience with the Artificial Kidney

Abstract

Medical History1 March 1965First Clinical Experience with the Artificial KidneyWILLEM J. KOLFF, M.D.WILLEM J. KOLFF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-3-608 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs the youngest volunteer assistant in the Department of Medicine at the University of Gronigen in The Netherlands I had the care of four beds, or rather of the patients that were in them. One of my first patients was a young man suffering from chronic nephritis and slowly dying of renal failure. He was hypertensive, had headaches, became blind, and was vomiting every day. His old mother was the wife of a poor farmer, her back bent by hard work, dressed in her traditional Sunday black dress, but with a very pretty white lace cap. I had to tell...References1. KOLFF WJ: De Kunstmatige Nier. J. H. Kok, Kempen, The Netherlands, 1946, 200 pages. Google Scholar2. KOLFF WJ: New Ways of Treating Uraemia. J. & A. Churchill, Ltd., London, 1947, 112 pages. Google Scholar3. KOLFFBERK WJHJ: De kunstmatige nier: een dialysator met groot oppervlak. Geneesk. Gids. 21: No. 7, 1943; Nederl. T. Geneesk. 87: No. 46/47, 1943. Google Scholar4. KOLFFBERK WJHJ: The artificial kidney: a dialyser with a great area. Acta Med. Scand. 117: Fasc. II, 1944. Google Scholar5. KOLFF WJ: Artificial kidney. Cleveland Clin. Quart. 17: No. 4, 1952. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, OhioFrom the Cleveland Clinic, Cleveland, Ohio.Requests for reprints should be addressed to Willem J. Kolff, M.D., Cleveland Clinic, 2020 East 93rd St., Cleveland, Ohio 44106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArtero-venous fistulas for hemodialysis: surgical and endovascular approachesNotes on the History of Dialysis Therapy in ChildrenNierenversagen bei Intensivpatienten: Benefit durch frühe Ersatztherapie?CLINICAL PROFILE AND OUTCOME OF PEDIATRIC MAINTENANCE HEMODIALYSIS A PROSPECTIVE, OBSERVATIONAL, HOSPITAL BASED STUDY.Preparation of gradient-type biological tissue–polymer complex for interlinking deviceAdvances in Diagnosis and Management of Secondary and Tertiary HyperparathyroidismVascular access for hemodialysis: A perpetual challengeThe History of Dialysis and TransplantationHAEMODYNAMIC STABILITY OF CKD PATIENTS UNDERGOING DIALYSIS AT ISOTHERMIC DIALYSATE TEMPERATUREA brief history of haemodialysis and continuous renal replacement therapyPeritoneal Dialysis SystemPrinciples of HemodialysisThe Intensity of Renal Replacement Treatment for Acute Kidney Injury: A Systematic Review and Network Meta-AnalysisHistorical Perspectives on Hemodialysis AccessRRT in AKI: Start Early or Wait?Dialysate Sodium: Choosing the Optimal Hemodialysis BathAcute Kidney InjuryAcute Kidney Injury in Cancer PatientsCon: Randomized controlled trials (RCT) have failed in the study of dialysis methodsThe role of technological progress vs. accidental discoveries and clinical experienceTherapeutic Removal of Uremic Toxins by HemodialysisWillem J Kolff (1911–2009): physician, inventor and pioneer: father of artificial organsBrief History of Kidney DiseaseSection 5: Dialysis Interventions for Treatment of AKIReferencesNotes on the History of Dialysis Therapy in ChildrenPharmacokinetics in Patients Requiring Renal Replacement TherapyAcute Kidney InjuryHemodialysisDesign of Medical Membrane and its Performance when Contacting BloodAn experimental and numerical study of the flow and mass transfer in a model of the wearable artificial kidney dialyzerBenefits of Ultrafiltration for Pulmonary FunctionMembranes for Dialysis and HemofiltrationEpidemiology of Acute Kidney InjuryEmergency Dialysis and UltrafiltrationPrinciples of HemodialysisThe development of vascular access for haemodialysis, part 2Willem J. Kolff: A great manHistory and Development of Acute Dialysis TherapyRenal Replacement Techniques: Descriptions, Mechanisms, Choices, and ControversiesThe Peritoneal Dialysis SystemHistory of Technology in the Intensive Care UnitGlucose in the dialysateTiming of Renal Replacement Therapy Initiation in Acute Renal Failure: A Meta-analysisIntensity of Renal Support in Critically Ill Patients with Acute Kidney InjuryHistory of hemodialyzers' designsVascular Access for Dialysis, Chemotherapy, and Nutritional SupportHemodiafiltration History, Technology, and Clinical ResultsLong-term outcome of acute tubular necrosis: A contribution to its natural historyTreatment of acute kidney injury: an update on the management of renal replacement therapyPharmacokinetics in Patients Requiring Renal Replacement TherapyUNRESOLVED ISSUES IN DIALYSIS: Dialysis Modality and Dosing Strategy in Acute Renal FailureHistory of vascular access for haemodialysisPreoperative Ultrasound Assessment for Dialysis Access PlacementRenal Replacement Therapy I: Indications and TimingHome hemodialysisDelayed creative destruction and the coexistence of technologiesRadiological Evaluation of A Failing Dialysis FistulaThe artificial kidney and its effect on the development of other artificial organsAcute renal failure due to crush syndrome during Marmara earthquakeHemodialyzer: From macro-design to membrane nanostructure; the case of the FX-class of hemodialyzersFactors Affecting Hemodialysis and Peritoneal Dialysis EfficiencyKidney Transplantation and Dialysis AccessVascular Access for CancerThe Kidney in Canada and the USAPractical haemodialysis began with cellophane and heparin: the crucial role of William Thalhimer (1884–1961)From intensive care to treatment of the critically illThe first successful haemodialysisKolff's Credo: New Ways of Thinking!Kolff and Who?Dialytic Therapy in Acute Renal Failure: No Reason for NihilismScience, Inventors, and the Introduction of the Artificial Kidney in the United StatesComplications associated with the use of central venous access devicesA Brief History of Home HemodialysisForgotten Paths in Medicine: The Case of the Low Protein Diet in Chronic Renal FailureOrgan Transplantation and the Revitalization of ImmunologyDelays by Recalcitrant FDA, Reluctant NIH, and Fearful Industry: The Cost in Human Life, Happiness, Money, and Loss of Opportunity for American IndustryThe Beginning of the Artificial KidneySelection of patients for kidney transplantationAcute renal support in the ITUHuman Organ Transplantation: Background and ConsequencesThe Intensive Care Unit: The Unfolding and Ambiguities of Survival Therapy50 years on: the crush syndrome.Theoretical and experimental analysis of a hybrid bioartificial membrane pancreas: a distributed parameter model taking into account starling fluxesRenal dialysisAcute Renal FailureHaemodialysis: A Historical ReviewInnovative extracorporeal membrane systemsRenal disease 1947–1987Realization of Missed OpportunitiesNephrology in the United States from Osler to the Artificial KidneySTEVEN J. PEITZMAN, M.D.Ultrafiltration/Hemofiltration Overview: Where Does CAVH Fit?The Future of HemofiltrationSynthetic Polymeric Membranes: Biological ApplicationsDie technisch-apparative Entwicklung der DialyseRenal Replacement Therapy Utilizing Hemodialysis and Peritoneal DialysisHaemodialysis: A Historical ReviewAcute Renal FailureDialysisIntermittent hemodialysis therapy in the cancer patientINTERMITTENT PERITONEAL DIALYSIS IN THE TREATMENT OF END‐STAGE RENAL FAILUREHaemodialysis: A Historical ReviewDetoxikationsverfahren in der MedizinMedizinische Extremsituationen und der sterbende PatientSurgeryThe Human KidneyDialysis as a substitute for renal function in surgical patientsAcute Renal FailureDialysis in Older PatientsMANAGEMENT OF UREMIA IN OLDER PATIENTS: HEMODIALYSIS AND RENAL TRANSPLANTATION*Current status of chronic hemodialysisChronic Hemodialysis as a Medical and Social ExperimentCHARLES E. NORTON, M.D.The Artificial Kidney: Some Approaches to Improved Design and FunctionAcute Renal Failure in Surgery Conditions 1 March 1965Volume 62, Issue 3Page: 608-619KeywordsKidneysNephritisRenal failureVomiting Issue Published: 1 March 1965 PDF downloadLoading ...