Peripheral Blood Mononuclear Cell DNA 6-Thioguanine Metabolite Levels Correlate with Decreased Interferon-γ Production in Patients with Crohn's Disease on AZA Therapy

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

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Treatment of Crohn's Disease with 6-Mercaptopurine

Daniel H. Present, Burton I. Korelitz, Nathaniel Wisch et al. · New England Journal of Medicine · 1980 · 1K citations

Pharmacy, Pharmacology, Pharmacotherapy +13

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

Marla C. Dubinsky, Stéphanie Lamothe, Hui Ying Yang et al. · Gastroenterology · 2000 · 1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

William E. Evans, Michelle Horner, Ya Qin Chu et al. · The Journal of Pediatrics · 1991 · 399 citations

Medicine, Pharmacology, Toxicology +17

6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity.

Carmelo Cuffari, Yves Théorêt, S. LATOUR et al. · Gut · 1996 · 332 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16