Concepedia

Role of Reactive Oxygen Species in Hypertension Produced by Reduced Uterine Perfusion in Pregnant Rats

Mona Sedeek, Jeffrey S. Gilbert, Birdie LaMarca, Myssara Sholook, Danielle L. Chandler, Y. Wang, Joey P. Granger

American Journal of Hypertension · 2008 · 131 citations · 26 references

DOIFull text

Open access

Abstract

The results of this study indicate that placental ischemia decreases innate antioxidant activity resulting in elevated oxidative stress which appears to play a role in mediating hypertension associated with chronic RUPP in pregnant rats.

References

26

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

Jason D. Morrow, Kristina E. Hill, Raymond F. Burk et al. · Proceedings of the National Academy of Sciences · 1990 · 1.9K citations · Full text

, , +17

Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial

Lucy C. Chappell, Paul T. Seed, Annette Briley et al. · The Lancet · 1999 · 792 citations

, , +12

Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial

Lucilla Poston, FJ Kelly · The Lancet · 2006 · 750 citations

, , +11

Oxidative Stress in the Pathogenesis of Preeclampsia

Carl A. Hubel · Proceedings of The Society for Experimental Biology and Medicine · 1999 · 672 citations

, , +17

Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic

Christine G. Schnackenberg, William J. Welch, Christopher S. Wilcox · Hypertension · 1998 · 494 citations · Full text

, , +16