Concepedia

PRELIMINARY COMMUNICATION The Novel Bis(benzoxazole) Cytotoxic Natural Product UK-1 Is a Magnesium Ion-Dependent DNA Binding Agent and Inhibitor of Human Topoisomerase II

Michael B. Reynolds, Mark R. DeLuca, Sean M. Kerwin

Bioorganic Chemistry · 1999 · 64 citations · 23 references

Concepts

Medicinal ChemistryMedicineNatural SciencesNovel BisHuman Topoisomerase IiPreliminary CommunicationAnti-cancer AgentDrug DevelopmentChemical BiologyPharmacologyRadiation OncologyDrug Discovery

References

23

Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice

James D. McGhee, Peter H. von Hippel · Journal of Molecular Biology · 1974 · 2.9K citations

Protein Assembly, Dna-protein Interactions, Protein Folding +9

Excited-State Intramolecular Proton Transfer in 2-(2-Hydroxyphenyl)benzimidazole and -benzoxazole: Effect of Rotamerism and Hydrogen Bonding

Kaustuv Das, Nilmoni Sarkar, Ajit Ghosh et al. · The Journal of Physical Chemistry · 1994 · 278 citations

Molecular Sciences, Biochemistry, Donut Icon +11

Theory of continuous variations plots and a new method for spectrophotometric determination of extraction and formation constants

W. Likussar, D. F. Boltz · Analytical Chemistry · 1971 · 257 citations

Quantitative Methods, Engineering, Databases +28

UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

M. Ueki, Keiichi Ueno, Shinji Miyadoh et al. · The Journal of Antibiotics · 1993 · 122 citations · Full text

Self-Assembly of a Quinobenzoxazine-Mg2+ Complex on DNA: A New Paradigm for the Structure of a Drug-DNA Complex and Implications for the Structure of the Quinolone Bacterial Gyrase-DNA Complex

Jun-Yao Fan, Daekyu Sun, Hongtao Yu et al. · Journal of Medicinal Chemistry · 1995 · 95 citations