Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system

Cre recombinase: The universal reagent for genome tailoring

András Nagy · genesis · 2000 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +16

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

G Urlaub, Lawrence A. Chasin · Proceedings of the National Academy of Sciences · 1980 · 910 citations

Life Sciences, Genetics, Molecular Genetics +9

Repeat-induced gene silencing in mammals

David Garrick, Steven Fiering, David I. K. Martin et al. · Nature Genetics · 1998 · 897 citations

Life Sciences, Genetics, Molecular Biology +8

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

Brian Zambrowicz, Akira Imamoto, Steve Fiering et al. · Proceedings of the National Academy of Sciences · 1997 · 871 citations

Life Sciences, Genetics, Molecular Genetics +17

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

Yumi Kanegae, Gwang Lee, Yumi Sato et al. · Nucleic Acids Research · 1995 · 613 citations · Full text

Life Sciences, Genetics, Molecular Biology +13