Concepedia

Genotoxicity of Acyl Glucuronide Metabolites Formed from Clofibric Acid and Gemfibrozil: A Novel Role for Phase-II-Mediated Bioactivation in the Hepatocarcinogenicity of the Parent Aglycones?

Benedetta C. Sallustio, Louise A. Harkin, Mana Mann, Sara J. Krivickas, Philip Burcham

Toxicology and Applied Pharmacology · 1997 · 47 citations · 18 references

DOI

Concepts

References

18

Mutational specificity of depurination.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1984 · 361 citations · Full text

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Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.

Richard Bucala, Peter Model, Anthony Cerami · Proceedings of the National Academy of Sciences · 1984 · 210 citations · Full text

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Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes

Urs A. Boelsterli · Toxicology and Applied Pharmacology · 1993 · 172 citations

, , +14

Identification of N2-(1-Carboxyethyl)guanine (CEG) as a Guanine Advanced Glycosylation End Product

Andrew T. Papoulis, Yousef Al‐Abed, Richard Bucala · Biochemistry · 1995 · 161 citations

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Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.

A Ding, Joseph C Ojingwa, Antony F. McDonagh et al. · Proceedings of the National Academy of Sciences · 1993 · 135 citations

, , +17