Concepedia

O6-(4-Bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro

Mario Turriziani, Patrizia Caporaso, Laura Bonmassar, Francesco Buccisano, Sergio Amadori, Adriano Venditti, Maria Cantonetti, Stefania D’Atri, Enzo Bonmassar

Pharmacological Research · 2006 · 41 citations · 39 references

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References

39

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

Morten Hansen, Svend Erik Nielsen, Kurt Berg · Journal of Immunological Methods · 1989 · 3.5K citations

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

M. Eileen Dolan, Robert C. Moschel, Anthony E. Pegg · Proceedings of the National Academy of Sciences · 1990 · 459 citations · Full text

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The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

Ram N. Trivedi, Karen H. Almeida, Jamie L. Fornsaglio et al. · Cancer Research · 2005 · 244 citations

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

Lili Liu, Sanford D. Markowitz, Stanton L. Gerson · PubMed · 1996 · 237 citations

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Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

Anthony E. Pegg, Laurie Wiest, Robert S. Foote et al. · Journal of Biological Chemistry · 1983 · 183 citations · Full text

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