Action of atrop‐Abyssomicin C as an Inhibitor of 4‐Amino‐4‐deoxychorismate Synthase PabB

Abstract

Subtle restraint: Abyssomicin C and atrop-abyssomicin C are polyketide-type antibiotics produced by the marine actinomycete of the genus Verrucosispora. Investigations of the functional pathway show that a subunit of 4-amino-4-deoxychorismate synthase from Bacillus subtilis is irreversibly inhibited through covalent binding to the side chain of Cys 263, undergoing a rearrangement to a structure of the abyssomicin D type (see scheme).