Applied Optics · 2004 · 121 citations · 21 references
EngineeringBiomedical EngineeringOncologyBiomedical OpticsBiophotonicsOpticsEndoscopic InstrumentsFluorescence ImagingLight-tissue InteractionOptical Coherence TomographyOptical TomographyTissue OpticsEndoscope DesignEndoscopic Optical ImagingEndoscopic Optical TomographyFluorescence EndoscopyLaser-induced FluorescenceLaser-induced Fluorescence SpectroscopyMiniature Endoscopic ImagingOptical Coherence Tomography Instrumentation
We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides approximately 18-microm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.
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Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
Li-Kuo Su, Kenneth W. Kinzler, Bert Vogelstein et al. · Science · 1992 · 1.5K citations