The Expression of Programmed Death-1 in Circulating CD4⁺and CD8⁺T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics

Abstract

PD-1 expression in peripheral CD4(+) and CD8(+) T cells is dynamic, changes with HBV infection progression, and is related to HBV viral load and liver function, especially in CHB. PD-1 expression could be utilized as a potential clinical indicator to determine the extent of virus replication and liver injury.